Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity.

@article{Bernhardt2009IronCO,
  title={Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity.},
  author={Paul V. Bernhardt and Philip C. Sharpe and Mohammad Islam and David B. Lovejoy and Danuta S Kalinowski and Des R Richardson},
  journal={Journal of medicinal chemistry},
  year={2009},
  volume={52 2},
  pages={
          407-15
        }
}
We previously reported a series of di-2-pyridylketone thiosemicarbazone (HDpT) chelators that showed marked and selective antitumor activity (Whitnall, M.; et al. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 14901-14906). To further understand their biological efficacy, we report the characterization and activity of their Mn(II), Co(III), Ni(II), Cu(II), and Zn(II) complexes. The X-ray crystal structures of four divalent (Mn, Ni, Cu, and Zn) and one trivalent (Fe) complexes are reported… Expand
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