Iron chelators as anti-neoplastic agents: current developments and promise of the PIH class of chelators.

@article{Lovejoy2003IronCA,
  title={Iron chelators as anti-neoplastic agents: current developments and promise of the PIH class of chelators.},
  author={David B. Lovejoy and Des R. Richardson},
  journal={Current medicinal chemistry},
  year={2003},
  volume={10 12},
  pages={
          1035-49
        }
}
The chelator currently used to treat iron (Fe) overload disease, desferrioxamine (DFO), has shown anti-proliferative activity against leukemia and neuroblastoma cells in vitro, in vivo and in clinical trials. Collectively, these studies suggest that Fe-deprivation may be a useful anti-cancer strategy. However, the efficacy of DFO is severely limited due to its poor ability to permeate cell membranes and bind intracellular Fe pools. These limitations have encouraged the development of other Fe… 

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