Iron chelator deferasirox rescued mice from Fas-induced fulminant hepatitis.

@article{Sato2011IronCD,
  title={Iron chelator deferasirox rescued mice from Fas-induced fulminant hepatitis.},
  author={Tsutomu Sato and Masayoshi Kobune and Kazuyuki Murase and Yukari Kado and Tetsuro Okamoto and Shingo Tanaka and Shohei Kikuchi and Hiroyuki Nagashima and Yutaka Kawano and Kohichi Takada and Satoshi Iyama and Koji Miyanishi and Yasushi Sato and Rishu Takimoto and Junji Kato},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2011},
  volume={41 7},
  pages={
          660-7
        }
}
AIM   Fulminant hepatitis is a disease characterized by development of hepatic failure due to severe liver cell injury. Orthotopic liver transplantation is the therapy proven to improve patient survival; however, less burdensome and safer strategies are required. In a previous study, we showed that iron was intimately involved in hepatocyte apoptosis by demonstrating that spontaneous development of fulminant hepatitis in Long-Evans cinnamon rats was prevented by feeding an iron-deficient diet… CONTINUE READING

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