Iron chelation therapy as a treatment for Pythium insidiosum in an animal model.

@article{Zanette2013IronCT,
  title={Iron chelation therapy as a treatment for Pythium insidiosum in an animal model.},
  author={R{\'e}gis Adriel Zanette and Sydney H Alves and Maiara Ben Pilotto and Carla Weiblen and Rafael Almeida Fighera and Patr{\'i}cia Wolkmer and Mariana Martins Flores and Janio M Santurio},
  journal={The Journal of antimicrobial chemotherapy},
  year={2013},
  volume={68 5},
  pages={
          1144-7
        }
}
OBJECTIVES Iron plays an important role in the pathogenesis of Pythium insidiosum. Human pythiosis frequently occurs in iron-overloaded thalassaemic patients and experimentally infected animals develop iron deficiency anaemia. Therefore, we sought to determine the in vitro and in vivo activities of the iron chelator deferasirox against P. insidiosum. METHODS In vitro, the MIC and minimum fungicidal concentration (MFC) values of deferasirox for 17 strains of P. insidiosum were determined in… CONTINUE READING
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