Iron chelation and neuroprotection in neurodegenerative diseases

  title={Iron chelation and neuroprotection in neurodegenerative diseases},
  author={Xuping Li and Joseph Jankovic and Weidong Le},
  journal={Journal of Neural Transmission},
Iron is an essential element for multiple functions of the brain. Maintenance of iron homeostasis involves regulation of iron influx, iron efflux and iron storage. Mismanagement of brain iron has been implicated in neuronal injury and death in several neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (PD) and Amyotrophic lateral sclerosis (ALS). Multiple iron chelators have been shown neuroprotective and neurorestorative in these diseases, suggesting that iron… CONTINUE READING