Iron catalysed assembly of an asymmetric mixed-ligand triple helicate.

@article{Bernhardt2004IronCA,
  title={Iron catalysed assembly of an asymmetric mixed-ligand triple helicate.},
  author={Paul V. Bernhardt and Piao Chin and Des R. Richardson},
  journal={Dalton transactions},
  year={2004},
  volume={20},
  pages={
          3342-6
        }
}
The 2-pyridinecarbaldehyde isonicotinoyl hydrazone (HPCIH) family of ligands are typically tridentate N,N,O chelators that exhibit very high in vitro activity in mobilizing intracellular Fe and are promising candidates for the treatment of Fe overload diseases. Complexation of ferrous perchlorate with HPCIH in MeCN solution gives the expected six-coordinate complex Fe(II)(PCIH)(2). However, complexation of Fe(II) with 2-pyridinecarbaldehyde picolinoyl hydrazone (HPCPH, an isomer of HPCIH) under… 

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References

SHOWING 1-10 OF 29 REFERENCES

Spiral Dinuclear Complexes of Tetradentate N(4) Diazine Ligands with Mn(II), Fe(II), Fe(III), Co(III), and Ni(II) Salts.

A series of dinuclear complexes of the tetradentate dipyridyl-diazine ligand PAHAP with Mn(II), Fe(II), Fe(III), Co(III), and Ni(II) salts is reported in which three ligands wrap themselves around

Trigonal bipyramidal geometry and tridentate coordination mode of the tripod in FeCl(2) complexes with tris(2-pyridylmethyl)amine derivatives bis-alpha-substituted with bulky groups. structures and spectroscopic comparative studies.

Electric conductivity measurements show that, for all complexes, the measured values lie within the same range, significantly below those expected for ionic complexes, which strongly suggests that the coordination mode of the tripod is retained in solution.

Characterization of the inhibitor complexes of cobalt carboxypeptidase A by electron paramagnetic resonance spectroscopy.

The metal coordination sphere of cobalt-substituted carboxypeptidase A and its complexes with inhibitors has been characterized by X-band electron paramagnetic resonance (EPR) spectroscopy and indicates an approximately axial symmetry of the cobalt atom in a moderately distorted tetrahedral metal environment.

Dimorphic YbPdSn with ZrNiAl and TiNiSi type structure

Two modifications of YbPdSn were prepared from the elements in sealed tantalum tubes at 870 K (α-YbPdSn) and 1400 K (β-YbPdSn). Both structures were refined from single crystal X-ray data: a-YbPdSn

Transition Ion Electron Paramagnetic Resonance

Part 1 Introduction to electron paragmanetic resonance: EPR due to mainly two-level systems some transition-ion EPR spectra crystal fields and ligand fields. Part 2 Crystal and ligand fields and the

Helices and Helicates: Beautiful Supramolecular Motifs with Emerging Applications

The fascination of scientists, and particularly supramolecular chemists, with helical arrays continues unabated [1,2]. These structures have provided the playground in which many supramolecular des...

WinGX suite for small-molecule single-crystal crystallography

The category Computer Program Abstracts provides a rapid means of communicating up-to-date information concerning both new programs or systems and signi®cant updates to existing ones. Following

ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI)

L Lists of software presented and~or reviewed in the Journal of Applied Crystallography are available on the World Wide Web at the above address, together with information about the availability of the software where this is known.