Iron-bleomycin interactions with oxygen and oxygen analogues. Effects on spectra and drug activity.

Abstract

Despite extensive structural dissimilarities, iron . bleomycin complexes and heme-containing oxygenases display remarkable similarities in binding oxygen antagonists and in spectral properties deriving from bound iron. Fe(II)-bleomycin reversibly forms a complex with either CO or isocyanide (lambda max = 384 and 497 nm, respectively), either of which… (More)

Topics

7 Figures and Tables

Slides referencing similar topics