Iron-binding proteins and C-reactive protein in Nipple Aspirate Fluids: role of Iron-driven inflammation in breast cancer microenvironment?

@article{Mannello2010IronbindingPA,
  title={Iron-binding proteins and C-reactive protein in Nipple Aspirate Fluids: role of Iron-driven inflammation in breast cancer microenvironment?},
  author={Ferdinando Mannello and Gaetana Anna Maria Tonti and Patrizia Simone and Daniela Ligi and Virginia Medda},
  journal={American journal of translational research},
  year={2010},
  volume={3 1},
  pages={100-13}
}
Breast cancer, a worldwide disease with increasing incidence, develops from ductal/lobular epithelium. Nipple aspirate fluid (NAF), secreted from the breast ducts and lobules, can be analyzed to assess metabolic activity in breast microenvironment. Premalignant and malignant cell alterations may produce biochemical signals that deliver inflammatory proteins to the site. C-reactive protein (CRP), acute-phase protein considered a prognostic marker of inflammation, is frequently over-expressed in… CONTINUE READING