Iron and the liver.

  title={Iron and the liver.},
  author={Antonello Pietrangelo},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  volume={36 Suppl 1},
Humans have evolved to retain iron in the body and are exposed to a high risk of iron overload and iron-related toxicity. Excess iron in the blood, in the absence of increased erythropoietic needs, can saturate the buffering capacity of serum transferrin and result in non-transferrin-bound highly reactive forms of iron that can cause damage, as well as promote fibrogenesis and carcinogenesis in the parenchymatous organs. A number of hereditary or acquired diseases are associated with systemic… CONTINUE READING
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