Iron and the liver: acute effects of iron-loading on hepatic heme synthesis of rats. Role of decreased activity of 5-aminolevulinate dehydrase.

@article{Bonkowsky1983IronAT,
  title={Iron and the liver: acute effects of iron-loading on hepatic heme synthesis of rats. Role of decreased activity of 5-aminolevulinate dehydrase.},
  author={Herbert L. Bonkowsky and John F. Healey and Peter R. Sinclair and Jacqueline F. Sinclair and Steven I. Shedlofsky and George H. Elder},
  journal={The Journal of clinical investigation},
  year={1983},
  volume={71 5},
  pages={1175-82}
}
Acute iron loading of rats, by intraperitoneal administration of iron-dextran (500 mg Fe/kg body wt 18-20 h before killing) decreased by 30% the rate of conversion of 5-amino-[14C]levulinate ([14C]ALA) into heme as measured with a recently described procedure for liver homogenates (1981. Biochem. J. 198: 595-604). The decrease in conversion of labeled ALA… CONTINUE READING