Iron and proteins for iron storage and detoxification

@article{Chiancone2004IronAP,
  title={Iron and proteins for iron storage and detoxification},
  author={Emilia Chiancone and Pierpaolo Ceci and Andrea Ilari and Frederica Ribacchi and Simonetta Stefanini},
  journal={Biometals},
  year={2004},
  volume={17},
  pages={197-202}
}
Iron is required by most organisms, but is potentially toxic due to the low solubility of the stable oxidation state, Fe(III), and to the tendency to potentiate the production of reactive oxygen species, ROS. The reactivity of iron is counteracted by bacteria with the same strategies employed by the host, namely by sequestering the metal into ferritin, the ubiquitous iron storage protein. Ferritins are highly conserved, hollow spheres constructed from 24 subunits that are endowed with… CONTINUE READING
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