Iron and manganese homeostasis in chronic liver disease: relationship to pallidal T1-weighted magnetic resonance signal hyperintensity.

@article{Malecki1999IronAM,
  title={Iron and manganese homeostasis in chronic liver disease: relationship to pallidal T1-weighted magnetic resonance signal hyperintensity.},
  author={Elise A. Malecki and Attila G Devenyi and Todd F. Barron and Timothy J. Mosher and Paul J. Eslinger and Claire V Flaherty-Craig and Lorenzo Rossaro},
  journal={Neurotoxicology},
  year={1999},
  volume={20 4},
  pages={647-52}
}
The hyperintense signal in the globus pallidus of cirrhotic patients on T1-weighted magnetic resonance (MR) imaging has been postulated to arise from deposition of paramagnetic manganese2+ (Mn). Intestinal absorption of both iron and Mn are increased in iron deficiency; iron deficiency may therefore increase susceptibility to Mn neurotoxicity. To investigate the relationships between MR signal abnormalities and Mn and Fe status, 21 patients with chronic liver disease were enrolled (alcoholic… CONTINUE READING