Iron and brain disorders.

@article{Sadrzadeh2004IronAB,
  title={Iron and brain disorders.},
  author={S. M. Hossein Sadrzadeh and Yasi Saffari},
  journal={American journal of clinical pathology},
  year={2004},
  volume={121 Suppl},
  pages={
          S64-70
        }
}
Iron is the most important element in the body, essential for almost all types of cells, including brain cells. The role of iron in the brain has been known for years. Iron deficiency and iron excess have been associated with pathophysiology of different brain disorders. Iron deficiency has been reported to have a role in brain development and the pathophysiology of restless legs syndrome. Iron accumulation has been related to some neurologic disorders such as Alzheimer disease, Parkinson… 
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The reviewed literature strongly suggests that iron-induced oxidative stress is a central pathway in the pathogenesis of neurodegenerative disorders, including Alzheimer’s dementia and Parkinson disease.
NEUTRON ACTIVATION ANALYSIS OF MANGANESE, IRON AND ZINC IN A RODENT MODEL OF DYSMYELINATION
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The higher trend in manganese concentration observed within the 3 and 16 week old les rats in comparison to the controls, and the overall trend in increased iron in the … supports evidence suggesting thatManganese levels are associated with astrogliosis.
Iron, dopamine, genetics, and hormones in the pathophysiology of restless legs syndrome
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This manuscript will review what is known about the pathophysiology of RLS, especially as it relates to changes in iron, dopamine, genetics, and hormonal systems.
Appraising the Role of Iron in Brain Aging and Cognition: Promises and Limitations of MRI Methods
TLDR
The potential advantages and promises of MRI-based assessment of brain iron, summarizes recent findings and highlights the limitations of the current methodology are described.
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A significant increased concentration of brain iron is found in the neuronal systems, thought to be a cause of many neurodegenerative diseases.
Expression of Iron Transporters and Pathological Hallmarks of Parkinson’s and Alzheimer’s Diseases in the Brain of Young, Adult, and Aged Rats
TLDR
It is demonstrated that age has a region-specific effect on iron transport proteins along with iron content in the cortex, striatum, hippocampus, and substantia nigra, and the increased brain iron is associated with expression of the pathological hallmarks of AD and PD.
The Role of Iron and Other Trace Elements on Mental Development and Cognitive Function
TLDR
The effects of iron deficiency (ID) and anemia on cognitive function and the relationship between its statuses on developmental outcome and the state of the adult brain are reviewed.
Determinants of iron accumulation in the normal aging brain
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References

SHOWING 1-10 OF 91 REFERENCES
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TLDR
This review encompasses neurodegenerative disorders associated with both iron overload and deficiency to highlight areas where iron misregulation is likely to be important in the pathophysiology of several human brain diseases.
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TLDR
Iron deficiency in the central nervous system is known to cause motor impairment and cognitive deficits; more recently, it has been suggested that it may play a role in the pathophysiology of the restless leg syndrome.
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TLDR
Why a model for brain iron uptake must take into consideration the potentially competing influences on the endothelial cell between the status of iron in the brain versus the systemic iron status is discussed.
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TLDR
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TLDR
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TLDR
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TLDR
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