Iron-adjuvant interactions observed with diffuse reflectance spectroscopy.

@article{Bornstein1968IronadjuvantIO,
  title={Iron-adjuvant interactions observed with diffuse reflectance spectroscopy.},
  author={M. Bornstein and J. Lach and B. Munden},
  journal={Journal of pharmaceutical sciences},
  year={1968},
  volume={57 10},
  pages={
          1653-7
        }
}
Numerous adjuvants have been screened for the existence of chemical and physical interactions with iron compounds. Results indicate that calcium hydroxide, magnesium hydroxide, magnesium oxide, magnesium carbonate, magnesium citrate, zinc oxide, and potassium iodide do undergo large spectral and visual color changes on equilibration with ferrous sulfate in aqueous and nonaqueous systems. 
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Spectral information is presented on chemisorption-diffuse reflectance studies of metallic and nonmetallic adjuvant interaction with anthracene, prednisone, and hydrochlorothiazide. The systems
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TLDR
Spectral and visual color changes, elution studies, and accelerated fading techniques support the reflectance data presented and indicate that a metallic or polyfunctional adsorbent molecule is necessary for these interactions.
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Spectral data are presented for chemisorption studies of oxytetracycline and oxytetracycline HCI with a number of metallic adjuvants containing aluminum, calcium, magnesium, zinc, and sodium ions as
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TLDR
It was concluded that chelated, or complexed, iron is carried through the gastrointestinal tract with less loss and lower toxicity than is ionic iron.
STABILITY OF ASCORBIC ACID IN THE PRESENCE OF FERROUS AND FERRIC IONS.