Iron acquisition from Pseudomonas aeruginosa siderophores by human phagocytes: an additional mechanism of host defense through iron sequestration?

Abstract

Chelation of iron to iron-binding proteins is a strategy of host defense. Some pathogens counter this via the secretion of low-molecular-weight iron-chelating agents (siderophores). Human phagocytes possess a high-capacity mechanism for iron acquisition from low-molecular-weight iron chelates. Efficient acquisition and sequestration of iron bound to… (More)

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@article{Britigan2000IronAF, title={Iron acquisition from Pseudomonas aeruginosa siderophores by human phagocytes: an additional mechanism of host defense through iron sequestration?}, author={Bradley E. Britigan and G. T. Rasmussen and Oyebode Olakanmi and C. D. Cox}, journal={Infection and immunity}, year={2000}, volume={68 3}, pages={1271-5} }