Iron accumulation during cellular senescence in human fibroblasts in vitro.

  title={Iron accumulation during cellular senescence in human fibroblasts in vitro.},
  author={David W Killilea and Hani Atamna and Charles Liao and Bruce N. Ames},
  journal={Antioxidants & redox signaling},
  volume={5 5},
Iron accumulates as a function of age in several tissues in vivo and is associated with the pathology of numerous age-related diseases. The molecular basis of this change may be due to a loss of iron homeostasis at the cellular level. Therefore, changes in iron content in primary human fibroblast cells (IMR-90) were studied in vitro as a model of cellular senescence. Total iron content increased exponentially during cellular senescence, resulting in 10-fold higher levels of iron compared with… CONTINUE READING
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