Iron absorption from chewable vitamins with iron versus iron tablets: Implications for toxicity

@article{Lacouture1992IronAF,
  title={Iron absorption from chewable vitamins with iron versus iron tablets: Implications for toxicity},
  author={Peter G. Lacouture and Alan David Woolf},
  journal={Pediatric Emergency Care},
  year={1992},
  volume={8},
  pages={321–324}
}
The medical literature contains few, if any, reports of severe iron (Fe) poisonings from ingestion of chewable multivitamins with iron. One possible explanation for this observation is that iron from multivitamins is more poorly absorbed than iron from iron tablets. To compare iron absorption from multivations with iron absorption from ferrous fumarate tablets, male adult volunteers were given 6 mg of elemental Fe/kg body weight as chewable multivitamins with iron or as crushed ferrous fumarate… 

Comparison of the toxicities of two iron formulations in a swine model.

These results demonstrate increased local gastrointestinal toxicity following a large ingestion of solid iron tablets in a swine model, compared with chewable multivitamins with iron.

Efficacy of the Cation Exchange Resin, Sodium Polystyrene Sulfonate, to Decrease Iron Absorption

Investigation of the efficacy and safety of sodium polystyrene sulfonate to prevent absorption of iron in human volunteers found it is not an effective method of decontamination for iron overdose.

Studies on Multivitamins and Minerals Containing Formulations in Bangladesh

These formulations contain either higher or lower amount of active ingredients than their recommended dose, the lower dose having no therapeutic effect whereas the higher dose can create lots of complications.

Ferrous sulfate toxicity a review of autopsy findings

The morphologic and chemical analysis data provide information on the pathogenesis of ferrous sulfate poisoning; the vascular iron deposition may be related to subsequent hemorrhage in the liver the periportal necrosis is probably a direct cytopathic effect of the highest levels of iron carried to these cells by the portal blood flow.

Iron poisoning.

  • J. S. Fine
  • Medicine
    Current problems in pediatrics
  • 2000
The epidemiologic, clinical, animal, and laboratory science related to iron poisoning and its management is reviewed and an emphasis on excellent supportive care with an individualized approach to gastrointestinal decontamination and a selective use of antidotes is focus.

Whole bowel irrigation (WBI) in acute iron poisoning — case report

WBI seems to be beneficial in early stage of iron intoxication ensuring rapid and effective cleansing of gut, and decreasing toxin absorption, as well as providing supportive care and avoiding deferoxamine treatment.

Iron Ingestion: an Evidence-Based Consensus Guideline for Out-of-Hospital Management

This guideline is to assist poison center personnel in the appropriate out-of-hospital triage and initial management of patients with suspected ingestions of iron by describing the manner in which an ingestion of iron might be managed.

Common Culprits in Childhood Poisoning

Poison prevention efforts should also address the appropriate role of the poison information centre, and the use of child-resistant packaging and the secure storage of household substances are the basis of preventing unintentional exposures.

Serum Iron Concentrations and Symptoms of Acute Iron Poisoning in Children

To determine whether serum iron concentrations correlate with the development of symptoms of iron poisoning in children, a large number of children and adults with suspected iron-related illnesses were surveyed.