Iron Toxicity and Chelation Therapy

@article{Britton2002IronTA,
  title={Iron Toxicity and Chelation Therapy},
  author={Robert S. Britton and Katherine L. Leicester and Bruce R. Bacon},
  journal={International Journal of Hematology},
  year={2002},
  volume={76},
  pages={219-228}
}
Iron is an essential mineral for normal cellular physiology, but an excess can result in cell injury. Iron in low-molecular-weight forms may play a catalytic role in the initiation of free radical reactions. The resulting oxyradicals have the potential to damage cellular lipids, nucleic acids, proteins, and carbohydrates; the result is wide-ranging impairment in cellular function and integrity. The rate of free radical production must overwhelm the cytoprotective defenses of cells before injury… 

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