Iron Poisoning: A Literature-Based Review of Epidemiology, Diagnosis, and Management

@article{Chang2011IronPA,
  title={Iron Poisoning: A Literature-Based Review of Epidemiology, Diagnosis, and Management},
  author={Todd Pou-Yen Chang and Cyrus Rangan},
  journal={Pediatric Emergency Care},
  year={2011},
  volume={27},
  pages={978-985}
}
Although seen less frequently than acetaminophen or salicylate poisoning, acute iron poisoning remains a dangerous threat, particularly to pediatric patients. Multiple factors-including legal and manufacturing practices-have changed the landscape of iron poisoning over the decades. Despite these changes, diagnosis and management of iron poisoning have minimally evolved, and the current evidence for iron poisoning is yet based principally on case series, expert consensus, animal studies, and… Expand
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References

SHOWING 1-10 OF 97 REFERENCES
Iron: not a benign therapeutic drug
TLDR
Iron poisoning remains primarily a clinical diagnosis, although certain laboratory and radiological testing may provide helpful evidence to guide evaluation and management, and primary prevention is the best modality for decreasing morbidity and mortality for all poisonings. Expand
Acute iron poisoning. A review.
TLDR
Owing to current understanding of the pathophysiology of iron poisoning, it is believed that the simultaneous oral and continuous intravenous (IV) administration of deferoxamine offers the most rational specific therapy for this condition. Expand
Acute respiratory distress syndrome in children with acute iron poisoning: the role of intravenous desferrioxamine
TLDR
It is believed that the efficacy and safety of chelation therapy in severe acute iron poisoning may be improved by targeting the initial high levels of readily chelatable serum iron with adequate doses of desferrioxamine without prolonging its use unnecessarily. Expand
Benefits of parenteral deferoxamine for acute iron poisoning.
  • M. Tenenbein
  • Medicine
  • Journal of toxicology. Clinical toxicology
  • 1996
TLDR
Deferoxamine is attractive for the treatment of iron poisoning despite the lack of knowledge for its optimal use and remains the drug of choice for the Treatment of significant iron poisoning. Expand
Acute iron poisoning: clinical picture, intensive care needs and outcome.
TLDR
Dose of ingested iron and clinical signs were most useful guide to iron toxicity and management decisions; serumIron did not help; Desferrioxamine infusion and supportive care of shock was the mainstay. Expand
Acute iron poisoning in adult female
TLDR
A 27-year-old female with anemia, treated with high dose oral and parenteral iron therapy, and developed clinical manifestations characteristic of acute iron poisoning, probably due to the administration of iron doses over an extended period of time. Expand
Hepatotoxicity in acute iron poisoning
TLDR
The data support hepatotoxicity due to iron poisoning as a doserelated phenomenon with clinically important cases unlikely with a serum iron concentration of B / 700 mg/dL (128 mmol/L) within the first 12 hours. Expand
Iron poisoning.
TLDR
The prompt recognition and initiation of management of children with acute iron poisoning is the single most critical element in decreasing the morbidity and mortality associated with these products. Expand
Hepatotoxicity in Acute Iron Poisoning
  • M. Tenenbein
  • Medicine
  • Journal of toxicology. Clinical toxicology
  • 2001
TLDR
From the clinical perspective, the relatively high mortality rate of iron poisoning-induced hepatotoxicity requires vigilance for its onset and earlier consideration of liver transplantation and an understanding of the pathogenesis of the hepatot toxicity of acute iron poisoning is central to the identification of rational and effective interventions. Expand
Iron Ingestion: an Evidence-Based Consensus Guideline for Out-of-Hospital Management
TLDR
This guideline is to assist poison center personnel in the appropriate out-of-hospital triage and initial management of patients with suspected ingestions of iron by describing the manner in which an ingestion of iron might be managed. Expand
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