Iron Metabolism in Pathogenic Trypanosomes

  title={Iron Metabolism in Pathogenic Trypanosomes},
  author={Bruno Manta and L. Fleitas and M. Comini},
  • Bruno Manta, L. Fleitas, M. Comini
  • Published 2012
  • Biology
  • Trypanosomatids comprise a large group of flagellated unicellular protists with free-living and parasitic lifestyles. Several members of this family are widely known for being vertebrate pathogens of biomedical and veterinary importance. They belong to the order Kinetoplastida, which together with the groups Diplonemida (deep-see organisms) and Euglenida (photosynthetizing organisms) form the phylum Euglenozoa (Simpson et al., 2006; Roger & Simpson, 2009). Kinetoplastids represent one of the… CONTINUE READING
    4 Citations

    Figures from this paper

    Fe/S protein biogenesis in trypanosomes - A review.
    • 24
    • PDF
    Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids.
    • 73
    Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes.
    • 22
    • PDF
    In vitro activity and mode of action of distamycin analogues against African trypanosomes.
    • 9


    Evolution of the haem synthetic pathway in kinetoplastid flagellates: an essential pathway that is not essential after all?
    • 86
    • Highly Influential
    Metabolic functions of glycosomes in trypanosomatids.
    • 305
    • PDF
    The evolution and diversity of kinetoplastid flagellates.
    • 286
    Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways
    • 52
    • Highly Influential
    • PDF
    Porphyrin biosynthesis in parasitic hemoflagellates: functional and defective enzymes in Trypanosoma cruzi.
    • 39
    Stress Response in the Infective Stage of Trypanosoma brucei
    • 3
    Vitamin C biosynthesis in trypanosomes: a role for the glycosome.
    • 57
    • PDF
    Iron metabolism in trypanosomatids, and its crucial role in infection.
    • 69
    • PDF
    Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification.
    • 124
    The Genome of the African Trypanosome Trypanosoma brucei
    • 1,502
    • Highly Influential
    • PDF