Iron-Induced Inhibition of Na+, K+-ATPase and Na+/Ca2+ Exchanger in Synaptosomes: Protection by the Pyridoindole Stobadine

@article{Kapln1997IronInducedIO,
  title={Iron-Induced Inhibition of Na+, K+-ATPase and Na+/Ca2+ Exchanger in Synaptosomes: Protection by the Pyridoindole Stobadine},
  author={Peter Kapl{\'a}n and Milena Matejovi{\vc}ov{\'a} and Viera M{\'e}ze{\vs}ov{\'a}},
  journal={Neurochemical Research},
  year={1997},
  volume={22},
  pages={1523-1529}
}
The effect of oxidative stress, induced by Fe2+-EDTA system, on Na+,K+-ATPase, Na+/Ca2+ exchanger and membrane fluidity of synaptosomes was investigated. Synaptosomes isolated from gerbil whole forebrain were incubated in the presence of 200 μM FeSO4-EDTA per mg of protein at 37°C for 30 min. The oxidative insult reduced Na+,K+-ATPase activity by 50.7 ± 5.0 % and Na+/Ca2+ exchanger activity measured in potassium and choline media by 47.1 ± 7.2 % and 46.7 ± 8.6 %, respectively. Membrane fluidity… CONTINUE READING

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Neuroprotection by pyridoindole stobadine: a minireview

S. Stole, R. Vlkolinsky, J. Pavlasek
Brain Res . Bull • 1997
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