Iron-Induced Cardiac Damage: Role of Apoptosis and Deferasirox Intervention

@article{Wang2011IronInducedCD,
  title={Iron-Induced Cardiac Damage: Role of Apoptosis and Deferasirox Intervention},
  author={Yeling Wang and M. Wu and Rabaa M Al-Rousan and H. Liu and J. Fannin and S. Paturi and R. K. Arvapalli and A. Katta and Sunil K. Kakarla and K. M. Rice and W. Triest and E. Blough},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2011},
  volume={336},
  pages={56 - 63}
}
  • Yeling Wang, M. Wu, +9 authors E. Blough
  • Published 2011
  • Biology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
    • Excess cardiac iron levels are associated with cardiac damage and can result in increased morbidity and mortality. Here, we hypothesize that elevations in tissue iron can activate caspase-dependent signaling, which leads to increased cardiac apoptosis and fibrosis, and that these alterations can be attenuated by iron chelation. Using an iron-overloaded gerbil model, we show that increased cardiac iron is associated with reduced activation of Akt (Ser473 and Thr308), diminished phosphorylation… CONTINUE READING
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    References

    SHOWING 1-10 OF 43 REFERENCES
    Taurine Supplementation Reduces Oxidative Stress and Improves Cardiovascular Function in an Iron-Overload Murine Model
    • 178
    Deferasirox Decreases Age-Associated Iron Accumulation in the Aging F344XBN Rat Heart and Liver
    • 19
    Apoptotic stress pathway activation mediated by iron on endothelial cells in vitro.
    • 24
    • PDF
    Coenzyme Q10 provides neuroprotection in iron-induced apoptosis in dopaminergic neurons
    • 81
    Chronic acetaminophen attenuates age-associated increases in cardiac ROS and apoptosis in the Fischer Brown Norway rat
    • 30
    Deferasirox removes cardiac iron and attenuates oxidative stress in the iron‐overloaded gerbil
    • 22
    Aging-Associated Dysfunction of Akt/Protein Kinase B: S-Nitrosylation and Acetaminophen Intervention
    • 79
    • PDF
    Pro‐apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity
    • 47
    Apoptosis is prevented by administration of superoxide dismutase in dogs with reperfused myocardial infarction
    • 38
    Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy
    • 35