Iron-Induced Cardiac Damage: Role of Apoptosis and Deferasirox Intervention

  title={Iron-Induced Cardiac Damage: Role of Apoptosis and Deferasirox Intervention},
  author={Yeling Wang and Miaozong Wu and Rabaa M. Al-Rousan and Hua Liu and Jacqueline C. Fannin and Satyanarayana Paturi and Ravikumar Arvapalli and Anjaiah Katta and Sunil K. Kakarla and Kevin M Rice and William E. Triest and Eric R. Blough},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={56 - 63}
Excess cardiac iron levels are associated with cardiac damage and can result in increased morbidity and mortality. Here, we hypothesize that elevations in tissue iron can activate caspase-dependent signaling, which leads to increased cardiac apoptosis and fibrosis, and that these alterations can be attenuated by iron chelation. Using an iron-overloaded gerbil model, we show that increased cardiac iron is associated with reduced activation of Akt (Ser473 and Thr308), diminished phosphorylation… 

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