Iron-Induced Cardiac Damage: Role of Apoptosis and Deferasirox Intervention

  title={Iron-Induced Cardiac Damage: Role of Apoptosis and Deferasirox Intervention},
  author={Yeling Wang and M. Wu and Rabaa M Al-Rousan and H. Liu and J. Fannin and S. Paturi and R. K. Arvapalli and A. Katta and Sunil K. Kakarla and K. M. Rice and W. Triest and E. Blough},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={56 - 63}
  • Yeling Wang, M. Wu, +9 authors E. Blough
  • Published 2011
  • Biology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • Excess cardiac iron levels are associated with cardiac damage and can result in increased morbidity and mortality. Here, we hypothesize that elevations in tissue iron can activate caspase-dependent signaling, which leads to increased cardiac apoptosis and fibrosis, and that these alterations can be attenuated by iron chelation. Using an iron-overloaded gerbil model, we show that increased cardiac iron is associated with reduced activation of Akt (Ser473 and Thr308), diminished phosphorylation… CONTINUE READING
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