Iron Deficiency and Child Development

@article{Lozoff2007IronDA,
  title={Iron Deficiency and Child Development},
  author={B. Lozoff},
  journal={Food and Nutrition Bulletin},
  year={2007},
  volume={28},
  pages={S560 - S571}
}
  • B. Lozoff
  • Published 2007
  • Medicine
  • Food and Nutrition Bulletin
Iron deficiency is widespread in infants and young children, especially in developing countries. Animal models provide convincing evidence that, despite iron repletion, iron deficiency during the brain growth spurt alters metabolism and neurotransmission, myelination, and gene and protein profiles. In the human, there is compelling evidence that 6- to 24-month-old infants with iron-deficiency anemia are at risk for poorer cognitive, motor, social–emotional, and neurophysiologic development in… Expand
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References

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TLDR
This body of research emphasizes the importance of protecting the developing brain from ID, indicating that adverse effects can be prevented and/or reversed with iron earlier in development or before ID becomes severe or chronic. Expand
Has Iron Deficiency Been Shown to Cause Altered Behavior in Infants
Infancy is an especially important age at which to study behavioral effects of iron deficiency. Animal studies indicate that iron deficiency during early development has more lasting effects thanExpand
Iron status and neural functioning.
TLDR
Future studies with more specific measures of neurodevelopment in iron-deficient human infants, and animal models, will allow investigators to more clearly define causal roles of brain iron in neural development and functioning. Expand
Iron deficiency and behavioral development in infants and preschool children.
TLDR
In comparison to infants without signs of sideropenia, infants with iron deficiency with and without anemia tend to score lower in the Bayley Scale of Mental Development; conversely, there is no evidence for an association between iron deficiency and delayed motor development. Expand
Behavioral consequences of developmental iron deficiency in infant rhesus monkeys.
TLDR
It is indicated that different syndromes of behavioral effects are associated with prenatal and postnatal iron deprivation in rhesus monkey infants and that these effects can occur in the absence of concurrent iron deficiency as reflected in hematological measures. Expand
Variations in dietary iron alter behavior in developing rats.
TLDR
It is demonstrated that iron deficiency in early life leads to irreversible behavioral changes, and recovery from iron deficiency did not normalize these functional variables, showing that the deleterious effects of early iron deficiency persist despite subsequent adequate treatment. Expand
Moderate iron deficiency in infancy: Biology and behavior in young rats
TLDR
This approach of iron deficiency in utero and during lactation sufficient to cause moderate anemia but not stunt growth demonstrates that monaminergic metabolism changes occur prior to profound declines in brain iron concentration and is associated with developmental delays. Expand
Iron deficiency anemia and iron therapy effects on infant developmental test performance.
TLDR
Persistent lower scores suggest either that iron therapy adequate for correcting anemia is insufficient to reverse behavioral and developmental disturbances in many infants or that certain ill effects are long-lasting, depending on the timing, severity, or chronicity of iron deficiency anemia in infancy. Expand
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TLDR
It is suggested that mild iron deficiency has an effect on infant behavior that is rapidly reversible with iron therapy, and the rise in Mental Development Index was associated with improvement in attention span and cooperativeness. Expand
Behavioral and developmental effects of preventing iron-deficiency anemia in healthy full-term infants.
TLDR
The study shows that healthy full-term infants may receive developmental and behavioral benefits from iron supplementation in the first year of life. Expand
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