Iron Chelation Improves Endothelial Function in Patients With Coronary Artery Disease

@article{Duffy2001IronCI,
  title={Iron Chelation Improves Endothelial Function in Patients With Coronary Artery Disease},
  author={S. Duffy and E. Biegelsen and M. Holbrook and J. Russell and N. Gokce and J. Keaney and J. Vita},
  journal={Circulation: Journal of the American Heart Association},
  year={2001},
  volume={103},
  pages={2799-2804}
}
Background—Some epidemiological studies have shown that increased iron stores are associated with increased cardiovascular events. Redox-active iron may contribute to lipid peroxidation, endothelial cell activation, and generation of reactive oxygen species (especially hydroxyl radical, via Fenton chemistry). Increased oxidative stress is associated with impaired action of endothelium-derived nitric oxide in patients with atherosclerosis. Methods and Results—To test the hypothesis that reducing… Expand
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