Iron: mammalian defense systems, mechanisms of disease, and chelation therapy approaches.

@article{Kontoghiorghes1995IronMD,
  title={Iron: mammalian defense systems, mechanisms of disease, and chelation therapy approaches.},
  author={George J Kontoghiorghes and Eugene D. Weinberg},
  journal={Blood reviews},
  year={1995},
  volume={9 1},
  pages={33-45}
}
During the past 6 decades, much attention has been devoted to understanding the uses, metabolism and hazards of iron in living systems. A great variety of heme and non-heme iron-containing enzymes have been characterized in nearly all forms of life. The existence of both ferrous and ferric ions in low- and high-spin configuration, as well as the ability of the metal to function over a wide range of redox potentials, contributes to its unique versatility. Not surprisingly, the singular… CONTINUE READING

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