Iron, the substantia nigra and related neurological disorders.

  title={Iron, the substantia nigra and related neurological disorders.},
  author={Amanda M. Snyder and James R. Connor},
  journal={Biochimica et biophysica acta},
  volume={1790 7},
BACKGROUND Iron status is higher in the substantia nigra than in other brain regions but can fluctuate as function of diet and genetics and disease. Of particular note is the compartmentalization of the iron-enrichment in this region; the pars reticulata contains higher levels of stainable iron as compared to the pars compacta. The latter area is where the dopaminergic neurons reside. How this compartmentalization impacts the interpretation of data that iron contributes to cell death as in… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 58 extracted citations

Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice.

Proceedings of the National Academy of Sciences of the United States of America • 2016
View 4 Excerpts
Highly Influenced

Iron toxicity in neurodegeneration

BioMetals • 2012
View 3 Excerpts
Highly Influenced

Iron chelation and neuroprotection in neurodegenerative diseases

Journal of Neural Transmission • 2010
View 14 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…