Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

@article{Zecca2001IronNA,
  title={Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes},
  author={Luigi Zecca and Mario Gallorini and Volker Sch{\"u}nemann and Alfred Xaver Trautwein and Manfred Gerlach and Peter Franz Riederer and Paolo Vezzoni and Davide Tampellini},
  journal={Journal of Neurochemistry},
  year={2001},
  volume={76}
}
Information on the molecular distribution and ageing trend of brain iron in post‐mortem material from normal subjects is scarce. Because it is known that neuromelanin and ferritin form stable complexes with iron(III), in this study we measured the concentration of iron, ferritin and neuromelanin in substantia nigra from normal subjects, aged between 1 and 90 years, dissected post mortem. Iron levels in substantia nigra were 20 ng/mg in the first year of life, had increased to 200 ng/mg by the… 

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In vivo detection of iron and neuromelanin by transcranial sonography: A new approach for early detection of substantia nigra damage

  • L. ZeccaD. Berg G. Becker
  • Biology, Medicine
    Movement disorders : official journal of the Movement Disorder Society
  • 2005
The finding of a positive correlation between iron and ferritin levels and a negative correlation of neuromelanin content with the area of echogenicity at the SN could provide an interesting basis for diagnosis and therapeutic follow-up studies in PD.
...

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