Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

@article{Zecca2001IronNA,
  title={Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes},
  author={Luigi Zecca and Mario Gallorini and Volker Sch{\"u}nemann and Alfred Xaver Trautwein and Manfred Gerlach and Peter Franz Riederer and Paolo Vezzoni and Davide Tampellini},
  journal={Journal of Neurochemistry},
  year={2001},
  volume={76}
}
Information on the molecular distribution and ageing trend of brain iron in post‐mortem material from normal subjects is scarce. Because it is known that neuromelanin and ferritin form stable complexes with iron(III), in this study we measured the concentration of iron, ferritin and neuromelanin in substantia nigra from normal subjects, aged between 1 and 90 years, dissected post mortem. Iron levels in substantia nigra were 20 ng/mg in the first year of life, had increased to 200 ng/mg by the… Expand
Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability
TLDR
A comparative analysis of iron molecules during aging was performed in locus coeruleus (LC) and substantia nigra (SN), known targets of Parkinson’s Disease (PD) and related disorders, suggesting that in LC neurons iron mobilization and toxicity is lower than that in SN and is efficiently buffered by NM. Expand
The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging.
  • L. Zecca, A. Stroppolo, +12 authors F. Zucca
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
Data suggest that in LC neurons, the iron mobilization and toxicity is lower than that in SN and is efficiently buffered by NM, which may explain at least one of the reasons underlying lower vulnerability of LC compared to SN in Parkinsonian syndromes. Expand
Iron, the substantia nigra and related neurological disorders.
TLDR
This review attempts to provide a critical evaluation of the many avenues of exploration into the role of iron in one of the most iron-enriched and clinically investigated areas of the brain, the substantia nigra. Expand
ELISA reveals a difference in the structure of substantia nigra ferritin in Parkinson's disease and incidental Lewy body compared to control.
TLDR
The decrease of L ferritin in SN in PD and ILB may suggest that the whole process of neurodegeneration starts with a higher availability of free iron, which is released from the ferritIn shell. Expand
Specific visualization of neuromelanin-iron complex and ferric iron in the human post-mortem substantia nigra using MR relaxometry at 7T
TLDR
The aim of this study was to non‐invasively delineate the spatial distributions of paramagnetic magnetic susceptibility perturbers, such as NM‐iron complex and ferric iron in SN. Expand
Dissociation between iron accumulation and ferritin upregulation in the aged substantia nigra: attenuation by dietary restriction
TLDR
Iron chelation therapies and anti-inflammatory treatments may be putative ‘antibrain aging’ therapies and combining these strategies may be synergistic, it is suggested. Expand
Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging
TLDR
The absence of pronounced microgliosis, as well as a pronounced loss of NM-containing neurons, indicate the absence of neuroinflammation in human SN pars compacta during normal aging. Expand
The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease
TLDR
A continuous NM accumulation inSNPC neurons during aging, the presence of large amounts of NM in SNPC and severe depletion ofNM in Parkinson's disease are demonstrated. Expand
In vivo detection of iron and neuromelanin by transcranial sonography: A new approach for early detection of substantia nigra damage
  • L. Zecca, D. Berg, +7 authors G. Becker
  • Medicine
  • Movement disorders : official journal of the Movement Disorder Society
  • 2005
TLDR
The finding of a positive correlation between iron and ferritin levels and a negative correlation of neuromelanin content with the area of echogenicity at the SN could provide an interesting basis for diagnosis and therapeutic follow-up studies in PD. Expand
Lack of up‐regulation of ferritin is associated with sustained iron regulatory protein‐1 binding activity in the substantia nigra of patients with Parkinson's disease
TLDR
The data of this study suggest a ‘compartmentalized’ iron accumulation in Parkinson's disease and suggest a lack of up‐regulation of ferritin expression in cytoplasmic extracts of SNpc that would be normally expected with cytosolic iron accumulation. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 84 REFERENCES
Iron and Other Metals in Neuromelanin, Substantia Nigra, and Putamen of Human Brain
TLDR
Findings indicate that substantia nigra and putamen contain metals at higher concentrations than observed in blood and that neuromelanin has a particular affinity for metals. Expand
Decreased Ferritin Levels in Brain in Parkinson's Disease
TLDR
The failure of substantia nigra ferritin formation to be stimulated by increased iron levels suggests some defect in iron handling in this critical brain region in Parkinson's disease. Expand
A Quantitative Analysis of Isoferritins in Select Regions of Aged, Parkinsonian, and Alzheimer's Diseased Brains
TLDR
The analysis of isoferritin expression in brain provides insight into regional iron regulation under normal conditions and suggests a loss of ability to maintain iron homeostasis in the two disease states. Expand
Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains
TLDR
The results indicate that normally oligodendrocytes contain much of the iron and iron‐binding proteins found in the brain; and an increase in age is associated with altered cellular distribution of iron‐ binding proteins, but the altered distribution is specific to glial cells. Expand
Iron in parkinsonian and control substantia nigra—A mössbauer spectroscopy study
TLDR
Mössbauer spectroscopy found no difference in the total amount of iron in SN between PD and control brains, andMeasurements performed on fresh‐frozen, formalin‐fixed, and lyophilized samples demonstrated the presence of ferric (Fe3+) iron only, both inPD and control SN. Expand
Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains
TLDR
Reduced glutathione and the shift of the iron (II)/iron (III) ratio in favor of iron ( III) suggest that these changes might contribute to pathophysiological processes underlying PD. Expand
Brain iron and ferritin in Parkinson's and Alzheimer's diseases
TLDR
The results indicate a significant selective increase of Fe3+ and ferritin in substantia nigra zona compacta but not in zona reticulata of Parkinsonian brains, confirming the biochemical estimation of iron. Expand
Altered systemic iron metabolism in Parkinson's disease
TLDR
The results suggest the existence of a defect in the systems that regulate the synthesis of the major proteins of iron metabolism in the liver as well as the brain in Parkinson's disease that may, over time, expedite entry of iron into the brain and decrease iron in the extracellular compartment. Expand
Isoforms of ferritin have a specific cellular distribution in the brain
TLDR
The cellular distribution of the two isoforms of ferritin in the brain of adult subhuman primates is reported and considerable differences in iron sequestration and use between neurons and glia and among neuronal and glial subtypes are indicated. Expand
Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: an electron paramagnetic resonance spectroscopy study.
TLDR
The results of this study indicate that the spectra at g = 4.3, attributable to Fe3+, provides a useful parameter for determining the amount of paramagnetic iron bound to melanin, and this data together with the magnitude of the free radical signal from melanin provides an indication of the number ofIron bound to neuromelanin in intact human substantia nigra. Expand
...
1
2
3
4
5
...