Iron, hepcidin, and the metal connection

  title={Iron, hepcidin, and the metal connection},
  author={Olivier Lor{\'e}al and Thibault Cavey and Edouard Bardou-Jacquet and Pascal Guggenbuhl and Martine Ropert and Pierre Brissot},
  booktitle={Front. Pharmacol.},
Identification of new players in iron metabolism, such as hepcidin, which regulates ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron metabolism and iron-related diseases. However, from both experimental data and clinical findings, "iron-related proteins" appear to also be involved in the metabolism of other metals, especially divalent cations. Reports have demonstrated that some metals may affect, directly or indirectly, the expression of proteins… CONTINUE READING

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