Iron, brain ageing and neurodegenerative disorders

@article{Zecca2004IronBA,
  title={Iron, brain ageing and neurodegenerative disorders},
  author={L. Zecca and M. Youdim and P. Riederer and J. Connor and R. Crichton},
  journal={Nature Reviews Neuroscience},
  year={2004},
  volume={5},
  pages={863-873}
}
There is increasing evidence that iron is involved in the mechanisms that underlie many neurodegenerative diseases. Conditions such as neuroferritinopathy and Friedreich ataxia are associated with mutations in genes that encode proteins that are involved in iron metabolism, and as the brain ages, iron accumulates in regions that are affected by Alzheimer's disease and Parkinson's disease. High concentrations of reactive iron can increase oxidative-stress induced neuronal vulnerability, and iron… Expand
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References

SHOWING 1-10 OF 181 REFERENCES
Iron misregulation in the brain: a primary cause of neurodegenerative disorders
TLDR
An understanding of the process of iron regulation in the brain, the proteins important in this process, and the effects of iron misregulation could help to treat or prevent neurodegenerative disorders. Expand
Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders
TLDR
According to these findings, disruption in the expression of these proteins in the brain is probably one of the important causes of the altered brain iron metabolism in age-related neurodegenerative diseases, including Parkinson's Disease, Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis. Expand
Glutathione, iron and Parkinson's disease.
TLDR
There is a drastic depletion in cytoplasmic levels of the thiol tripeptide glutathione within the SN of PD patients, which might contribute to oxidative stress during PD. Expand
Neurodegenerative diseases and oxidative stress
TLDR
Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and different strategies, including novel metal–protein attenuating compounds aimed at a variety of targets have shown promise in clinical studies. Expand
Antioxidants as treatment for neurodegenerative disorders
TLDR
The major challenges for drug development are the slow kinetics of disease progression, the unsolved mechanistic questions concerning the final causalities of cell death, the necessity to attain an effective permeation of the blood–brain barrier and the need to reduce the high concentrations currently required to evoke protective effects in cellular and animal model systems. Expand
Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE
  • J. Pulliam, C. D. Jennings, +5 authors W. Markesbery
  • Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2003
TLDR
It is suggested that H FE mutations are associated with increased oxidative stress and Braak stage, and that HFE and APOE genotypes are different between AD patients, high pathology and low pathology controls. Expand
Is hemochromatosis a risk factor for Alzheimer's disease?
TLDR
It is proposed that the hemochromatosis mutation should be considered as a confounding factor when evaluating the contribution of genetic associations with AD and treatment strategies and efficacy. Expand
Indices of oxidative stress in Parkinson's disease, Alzheimer's disease and dementia with Lewy bodies.
TLDR
Evidence shows that in the substantia nigra there is altered iron metabolism, decreased levels of reduced glutathione and an impairment of mitochondrial complex I activity, but these changes seem to be unique to the substantian and have not been found in other areas of the brain known to be altered in Parkinson's disease, such as substantia innominata. Expand
Increasing striatal iron content associated with normal aging
TLDR
Striatal iron content increases with advancing age, therefore representing a risk factor for the development of neurodegenerative disorders such as PD in which nigrostriatal neurons may be affected by increased oxidant stress. Expand
Mouse brains deficient in H‐ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress
TLDR
A mouse model that mimics the protein profile for iron management seen in AD and PD that also shows evidence of oxidative stress is developed and is suggested that this mouse may be a model to determine the role of iron mismanagement in neurodegenerative disorders and for testing antioxidant therapeutic strategies. Expand
...
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4
5
...