Irniine, a pyrrolidine alkaloid, isolated from Arisarum vulgare can induce apoptosis and/or necrosis in rat hepatocyte cultures.

@article{Rakba2000IrniineAP,
  title={Irniine, a pyrrolidine alkaloid, isolated from Arisarum vulgare can induce apoptosis and/or necrosis in rat hepatocyte cultures.},
  author={N. Rakba and A. Melhaoui and M. Rissel and I. Morel and P. Loyer and G. Lescoat},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2000},
  volume={38 10},
  pages={
          1389-402
        }
}
The effects of irniine, a pyrrolidine alkaloid extracted from the tubers of Arisarum vulgare, on rat hepatocyte primary cultures and rat liver epithelial cell line (RLEC) were studied. Cytotoxicity was first evaluated by LDH release, MTT and NR tests and MDA production, while cellular alterations were visualized by electron microscopy and DNA gel-electrophoresis. In hepatocyte and RLEC cultures, a major toxicity appeared at 40 microM of irniine and was demonstrated by an increase in LDH release… Expand
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