Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

@article{Huh2014IrisinSM,
  title={Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans},
  author={Joo Young Huh and Fadime Dinçer and Ertirea T Mesfum and Christos S. Mantzoros},
  journal={International Journal of Obesity},
  year={2014},
  volume={38},
  pages={1538-1544}
}
  • Joo Young Huh, Fadime Dinçer, +1 author Christos S. Mantzoros
  • Published 2014
  • Medicine
  • International Journal of Obesity
  • Background:Irisin is a recently identified exercise-induced myokine suggested to induce browning of white adipocytes. Deficiency of myostatin, and thus stimulation of muscle growth, has also been reported to induce irisin and its precursor FNDC5 expression in muscle and drive the browning of white adipocytes in mice, implying that irisin may be related to muscle growth in addition to its beneficial effects in adipocytes. In humans, the effect of irisin in muscle hypertrophy as well as adipocyte… CONTINUE READING

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    Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle.