Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice.

@article{Lu2015IrisinPA,
  title={Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice.},
  author={Junyan Lu and Guangda Xiang and Min Liu and Wen-li Mei and Lin Xiang and Jing Dong},
  journal={Atherosclerosis},
  year={2015},
  volume={243 2},
  pages={438-48}
}
OBJECTIVE The circulating irisin increases energy expenditure and improves insulin resistance in mice and humans. The improvement of insulin resistance ameliorates atherosclerosis. Therefore, we hypothesized that irisin alleviates atherosclerosis in diabetes. METHODS Endothelial function was measured by acetylcholine-induced endothelium-dependent vasodilation using aortic rings in apolipoprotein E-Null (apoE(-/-)) streptozotocin-induced diabetic mice. Atherosclerotic lesion was evaluated by… CONTINUE READING
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