Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans.

@article{Lee2014IrisinAF,
  title={Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans.},
  author={Paul R Lee and Joyce D Linderman and Sheila M. Smith and Robert J. Brychta and Juan Wang and Christopher Idelson and Rachel M Perron and Charlotte D. Werner and Giao Q. Phan and Udai S. Kammula and Electron Kebebew and Karel Pacak and Kong Y. Chen and Francesco Saverio Celi},
  journal={Cell metabolism},
  year={2014},
  volume={19 2},
  pages={302-9}
}
Rediscovery of cold-activated brown adipose tissue (BAT) in humans has boosted research interest in identifying BAT activators for metabolic benefits. Of particular interest are cytokines capable of fat browning. Irisin, derived from FNDC5, is an exercise-induced myokine that drives brown-fat-like thermogenesis in murine white fat. Here we explored whether… CONTINUE READING