Irinotecan or oxaliplatin combined with leucovorin and 5-fluorouracil as first-line treatment in advanced colorectal cancer: a multicenter, randomized, phase II study.

@article{Kalofonos2005IrinotecanOO,
  title={Irinotecan or oxaliplatin combined with leucovorin and 5-fluorouracil as first-line treatment in advanced colorectal cancer: a multicenter, randomized, phase II study.},
  author={Haralambos P. Kalofonos and Gerassimos Aravantinos and Paris A. Kosmidis and Pavlos Papakostas and Theofanis C. Economopoulos and Meletios Athanasios Dimopoulos and Dimosthenis Skarlos and Aristotelis Bamias and Dimitrios G Pectasides and Sonia Chalkidou and Maria Karina and Aggelos Koutras and Epaminontas Samantas and Charalampos Bacoyiannis and Georgios Fotios Samelis and Georgios Basdanis and Fotios Kalfarentzos and George Fountzilas},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2005},
  volume={16 6},
  pages={
          869-77
        }
}
BACKGROUND Irinotecan (IRI) and oxaliplatin (OXA) are effective in the treatment of colorectal cancer. Previously untreated patients with advanced colorectal carcinoma (CRC) were randomly assigned to receive IRI plus leucovorin (LV)/5-fluorouracil (5-FU), or OXA plus LV/5-FU in order to compare the response rates, time-to-tumor progression, overall survival rates, and toxicity profiles of these two agents. MATERIALS AND METHODS From January 1999 to February 2002, 295 patients were randomized… CONTINUE READING
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