Irinotecan (CPT-11) and characteristic mucosal changes in the mouse ileum and cecum.

@article{Ikuno1995IrinotecanA,
  title={Irinotecan (CPT-11) and characteristic mucosal changes in the mouse ileum and cecum.},
  author={Nobuhiro Ikuno and Hiroshi Soda and Masahiko Watanabe and Masahiro Oka},
  journal={Journal of the National Cancer Institute},
  year={1995},
  volume={87 24},
  pages={
          1876-83
        }
}
BACKGROUND Irinotecan--or CPT-11; 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy-camptotheci n--is an inhibitor of DNA topoisomerase I and is clinically effective against several cancers. A major toxic effect of CPT-11 is severe diarrhea; however, the exact mechanism by which the drug induces diarrhea has not been established. Cisplatin (CDDP; cis-diamminedichloroplatinum) and CPT-11 exhibit synergistic antitumor activity and have been used in combination-chemotherapy regimens. Single… CONTINUE READING
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Case Report: Diffuse Mucosal Damage in the Large Intestine Associated with Irinotecan (CPT-11)

  • Digestive Diseases and Sciences
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