Irinotecan (CPT-11): a brief overview.

  title={Irinotecan (CPT-11): a brief overview.},
  author={Laurent P. Rivory},
  journal={Clinical and experimental pharmacology & physiology},
  volume={23 10-11},
1. Irinotecan (also known as CPT-11) is a water soluble, semi-synthetic analogue of 20(S)camptothecin (CPT) with promising activity against a range of tumour types. 2. As with all other active analogues of CPT, irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA. This leads to replication fork-arrest, double DNA strand breaks and, possibly, illegitimate recombination of vital genes. 3. This activity is much… CONTINUE READING


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