Iridium‐Catalyzed Intramolecular Asymmetric Allylic Dearomatization Reaction of Pyridines, Pyrazines, Quinolines, and Isoquinolines.

@article{Yang2016IridiumCatalyzedIA,
  title={Iridium‐Catalyzed Intramolecular Asymmetric Allylic Dearomatization Reaction of Pyridines, Pyrazines, Quinolines, and Isoquinolines.},
  author={Ze-Peng Yang and Qing-Feng Wu and W. L. Shao and Shu‐Li You},
  journal={ChemInform},
  year={2016},
  volume={47}
}
1 Citations
Applications of Iridium-Catalyzed Asymmetric Allylic Substitution Reactions in Target-Oriented Synthesis.
TLDR
The iridium-catalyzed allylic substitution with subsequent ring closing metathesis is a powerful strategy for their synthesis, and some fairly complex targets, for example, the potent nitric oxide inhibitor and the drug (-)-protrifenbute, have been synthesized via less than five steps from simple starting materials.

References

Iridium-Catalyzed Intramolecular Asymmetric Allylic Dearomatization Reaction of Pyridines, Pyrazines, Quinolines, and Isoquinolines.
TLDR
The first Ir-catalyzed intramolecular asymmetric allylic dearomatization reaction of pyridines, pyrazines, quinolines, and isoquinolines has been developed and the results suggest the feasibility of an alternative process which features the formation of a quinolinium as the key intermediate.