Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis.


In vertebrates, myeloid cells comprise polymorphonuclear and mononuclear lineages that arise from 2 successive waves of development: a transitory primitive wave giving rise to limited myeloid cells during embryonic stage and a definitive wave capable of producing myeloid cells throughout the fetal and adult life. One key unresolved question is what factors… (More)
DOI: 10.1182/blood-2010-06-290700


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