Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae.

@article{Balansa2010IrcinialactamsSG,
  title={Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae.},
  author={Walter Balansa and Robiul Islam and Frank Fontaine and Andrew M Piggott and Hua Zhang and Timothy I. Webb and Daniel Friedrich Gilbert and Joseph W Lynch and Robert J Capon},
  journal={Bioorganic & medicinal chemistry},
  year={2010},
  volume={18 8},
  pages={
          2912-9
        }
}
Screening an extract library of >2500 southern Australian and Antarctic marine invertebrates and algae for modulators of glycine receptor (GlyR) chloride channels identified three Irciniidae sponges that yielded new examples of a rare class of glycinyl lactam sesterterpene, ircinialactam A, 8-hydroxyircinialactam A, 8-hydroxyircinialactam B, ircinialactam C, ent-ircinialactam C and ircinialactam D. Structure-activity relationship (SAR) investigations revealed a new pharmacophore with potent and… CONTINUE READING
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