Irbesartan in patients with heart failure and preserved ejection fraction.

@article{Massie2008IrbesartanIP,
  title={Irbesartan in patients with heart failure and preserved ejection fraction.},
  author={Barry M. Massie and Peter E. Carson and John J V McMurray and Michel Komajda and Robert McKelvie and Michael R. Zile and Susan D Anderson and Mark Donovan and Erik N. K. Iverson and Christoph Staiger and Agata Ptaszynska},
  journal={The New England journal of medicine},
  year={2008},
  volume={359 23},
  pages={2456-67}
}
BACKGROUND Approximately 50% of patients with heart failure have a left ventricular ejection fraction of at least 45%, but no therapies have been shown to improve the outcome of these patients. Therefore, we studied the effects of irbesartan in patients with this syndrome. METHODS We enrolled 4128 patients who were at least 60 years of age and had New York Heart Association class II, III, or IV heart failure and an ejection fraction of at least 45% and randomly assigned them to receive 300 mg… CONTINUE READING
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