Ipsi- and contralateral motor response using ultrasound-induced neurostimulation in deeply anesthetized mice

Abstract

Ultrasound neurostimulation has been proven capable of eliciting motor responses. However, the studies in sedated rodents presented problems with target specificity due to the use of low ultrasound frequencies (<700 kHz). Here, we show that focused ultrasound (FUS) in mega-Hz range was able to evoke motor responses in mice under deep anesthesia. Contralateral movements of the hind limbs were observed when sonications were carried out at +2 mm of Lambda and ±2 mm lateral of midline in three mice. Moreover, stimulating other regions of the somatosensory and cerebellum induced trunk and ipsilateral limb movements in all six mice. © 2015 The Authors. Published by Elsevier B.V. Peer-review under responsibility of the Scientific Committee of 2015 ICU Metz.

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@inproceedings{Kamimura2015IpsiAC, title={Ipsi- and contralateral motor response using ultrasound-induced neurostimulation in deeply anesthetized mice}, author={Hermes A. S. Kamimura and Shutao Wang and Hong Chen and Qi Wang and Christian Aurup and Antonio Adilton Olivera Carneiro and Elisa E. Konofagou}, year={2015} }