Intensity, Low-Frequency Ultrasound
- Y. e3511. Younan, T. Deffieux, +4 authors J-F
Ultrasound neurostimulation has been proven capable of eliciting motor responses. However, the studies in sedated rodents presented problems with target specificity due to the use of low ultrasound frequencies (<700 kHz). Here, we show that focused ultrasound (FUS) in mega-Hz range was able to evoke motor responses in mice under deep anesthesia. Contralateral movements of the hind limbs were observed when sonications were carried out at +2 mm of Lambda and ±2 mm lateral of midline in three mice. Moreover, stimulating other regions of the somatosensory and cerebellum induced trunk and ipsilateral limb movements in all six mice. © 2015 The Authors. Published by Elsevier B.V. Peer-review under responsibility of the Scientific Committee of 2015 ICU Metz.