Ipomeolides A and B, Resin Glycosides from Ipomoea pes-caprae and Combination Therapy of Ipomeolide A with Doxorubicin.

@article{Sura2019IpomeolidesAA,
  title={Ipomeolides A and B, Resin Glycosides from Ipomoea pes-caprae and Combination Therapy of Ipomeolide A with Doxorubicin.},
  author={Madhu Babu Sura and Mangala Gowri Ponnapalli and Suresh Annam and V. V. Pardhasaradhi Bobbili},
  journal={Journal of natural products},
  year={2019},
  volume={82 5},
  pages={
          1292-1300
        }
}
Two new resin glycosides, ipomeolides A (1) and B (2), both with an unusual nonlinear heteropentasaccharide core, along with five known compounds were isolated from the n-hexane/CHCl3 (1:1) extract of the aerial parts of Ipomoea pes-caprae. Ipomeolides A (1) and B (2) are macrolactone analogues of the rare (11 R)-jalapinolic acid, and macrolactonization occurred at C-2 of the second saccharide moiety. Compounds 1 and 2 show structural variation even in the pentasaccharide core. The structures… 
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References

SHOWING 1-10 OF 21 REFERENCES
Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides.
TLDR
Stoloniferin I (8) enhanced norfloxacin activity 8-fold when incorporated at a concentration of 5 microg/mL, therefore, this type of amphipathic oligosaccharide could be developed further to provide more potent inhibitors of this multidrug efflux pump.
Merremins A-G, resin glycosides from Merremia hederacea with multidrug resistance reversal activity.
Five new pentasaccharide resin glycosides, named merremins A-E (1-5), two new pentasaccharide resin glycoside methyl esters, named merremins F and G (6, 7), and four known resin glycosides,
Pentasaccharide resin glycosides from Ipomoea pes-caprae.
TLDR
Compounds 1-10 were evaluated for their potential to modulate multidrug resistance in the human breast cancer cell line MCF-7/ADR and the combined use of these new compounds increased the cytotoxicity of doxorubicin by 1.5-3.7-fold.
Self gelating isoracemosol A, new racemosaceramide A, and racemosol E from Barringtonia racemosa
TLDR
Phytochemical investigation into the CHCl3 extract of the fruits of Barringtonia racemosa resulted in the isolation of two new metabolites along with isoracemosol A and betulinic acid as known metabolites, which leads to the unexpected agglomerated porous-like morphology.
Structural investigation of resin glycosides from Ipomoea lonchophylla.
TLDR
A fraction from Ipomoea lonchophylla, which was toxic to mice, contained an inseparable mixture of resin glycosides with differing numbers of C5 ester groups on the hexasaccharide chain that was elucidated using high-field NMR spectroscopy, mass spectrometry, chemical studies, and comparison with known resin Glycosides.
Tricolorin A, major phytogrowth inhibitor from Ipomoea tricolor.
The allelopathic potential of Ipomoea tricolor (Convolvulaceae), used in Mexican traditional agriculture as a weed controller, has been demonstrated by measuring the inhibitory activity of organic
Oleanane-type isomeric triterpenoids from Barringtonia racemosa.
TLDR
Two new isomeric acylated oleanane-type triterpenoids along with three known compounds were isolated from the MeOH extract of the dried fruits of Barringtonia racemosa and were not active against HeLa and P388 D1 carcinoma cell lines.
Antispasmodic activity of beta-damascenone and E-phytol isolated from Ipomoea pes-caprae.
TLDR
Bioassay-guided fractionation of IPA resulted in isolation of the antispasmodically acting isoprenoids beta-damascenone and E-phytol, which were found to be in the same range as that of papaverine, a general spasmolytic agent.
alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus.
TLDR
Two new triterpenoids were obtained from the methanolic extract of seeds of Cichorium intybus along with 11 known compounds, and compounds 1, 1a, and 11 showed a good alpha-glucosidase inhibitory activity.
Resin glycoside constituents of Ipomoea pes-caprae (beach morning glory).
TLDR
Eight new resin glycosides, pescapreins X-XVII (1-8), were isolated from a lipophilic fraction of an ethanol extract of the entire plant of beach morning glory, Ipomoea pes-caprae, and evaluated biologically in terms of cancer cell line cytotoxicity, antibacterial and antifungal activity, and effects on the mu-opioid receptor.
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