IpgD, a protein secreted by the type III secretion machinery of Shigella flexneri, is chaperoned by IpgE and implicated in entry focus formation.

@article{Niebuhr2000IpgDAP,
  title={IpgD, a protein secreted by the type III secretion machinery of Shigella flexneri, is chaperoned by IpgE and implicated in entry focus formation.},
  author={Kirsten Niebuhr and Noureddine Jouihri and Abdelmounaa{\"i}m Allaoui and P. Gounon and Philippe J Sansonetti and Claude Parsot},
  journal={Molecular microbiology},
  year={2000},
  volume={38 1},
  pages={8-19}
}
Invasion of epithelial cells by Shigella flexneri involves entry and intercellular dissemination. Entry of bacteria into non-phagocytic cells requires the IpaA-D proteins that are secreted by the Mxi-Spa type III secretion machinery. Type III secretion systems are found in several Gram-negative pathogens and serve to inject bacterial effector proteins directly into the cytoplasm of host cells. In this study, we have analysed the IpgD protein of S. flexneri, the gene of which is located on the… CONTINUE READING

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