IpgB1 and IpgB2, two homologous effectors secreted via the Mxi-Spa type III secretion apparatus, cooperate to mediate polarized cell invasion and inflammatory potential of Shigella flexenri.

@article{Hachani2008IpgB1AI,
  title={IpgB1 and IpgB2, two homologous effectors secreted via the Mxi-Spa type III secretion apparatus, cooperate to mediate polarized cell invasion and inflammatory potential of Shigella flexenri.},
  author={Abderrahman Hachani and Lat{\'e}fa Biskri and Giacomo Rossi and Allison J. Marty and Robert M{\'e}nard and Philippe J Sansonetti and Claude Parsot and Guy Tran Van Nhieu and Maria Lina Bernardini and Abdelmounaa{\"i}m Allaoui},
  journal={Microbes and infection},
  year={2008},
  volume={10 3},
  pages={
          260-8
        }
}
Type III secretion systems (T3SS) are present in many pathogenic gram-negative bacteria and mediate the translocation of bacterial effector proteins into host cells. Here, we report the phenotypic characterization of S. flexneri ipgB1 and ipgB2 mutants, in which the genes encoding the IpgB1 and IpgB2 effectors have been inactivated, either independently or simultaneously. Like IpgB1, we found that IpgB2 is secreted by the T3SS and its secretion requires the Spa15 chaperone. Upon infection of… CONTINUE READING
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