IpaB mediates macrophage apoptosis induced by Shigella flexneri.

  title={IpaB mediates macrophage apoptosis induced by Shigella flexneri.},
  author={Arturo Zychlinsky and Brendan Kenny and Robert M{\'e}nard and Marie Christine Pr{\'e}vost and Ian Barry Holland and Philippe J Sansonetti},
  journal={Molecular microbiology},
  volume={11 4},
Shigella flexneri kills macrophages through apoptosis, involving the induction of host cell DNA fragmentation and characteristic morphological changes. Shigella can only cause damage if it escapes from the phagolysosome into the cytoplasm. The S. flexneri cytotoxic genes have been localized to the ipa operon of shigella's virulence plasmid. ipaB, C and D deletion mutants are not invasive and therefore not cytotoxic. In order to distinguish genes involved in the escape from the phagolysosome as… CONTINUE READING

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