Iopiperidol: nonionic iodinated contrast medium with promising anticoagulant and antiplatelet properties.

@article{Valenti1999IopiperidolNI,
  title={Iopiperidol: nonionic iodinated contrast medium with promising anticoagulant and antiplatelet properties.},
  author={Raffaella Valenti and Alessandro Motta and Sara Merlini and Alberto Morisetti and Piero Tirone},
  journal={Academic radiology},
  year={1999},
  volume={6 7},
  pages={
          426-32
        }
}
RATIONALE AND OBJECTIVES The purpose of this study was to determine the anticoagulant and antiplatelet characteristics of iopiperidol, a nonionic, triiodinated contrast agent. MATERIALS AND METHODS Anticoagulant effects of iopiperidol were assessed both in vitro and in vivo after single or repeated intravenous administrations to rats. To this aim, results of prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen tests were evaluated. To define better the… 
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References

SHOWING 1-10 OF 17 REFERENCES
Effect of various contrast media on coagulation, fibrinolysis, and platelet function. An in vitro and in vivo study.
TLDR
The in vivo results showed a negligible influence of CM on systemic hemostatic parameters, but catheter-derived samples indicated desirability of premedication with ASA or heparin, and the nonionic CM caused less discomfort than the ionic CM.
Effects of nonionic contrast media (CM) on the components of coagulation and complement systems.
TLDR
The results indicate that nonionic contrast media produce certain transient hematologic changes and should be further tested for their immunologic properties in order to establish their absolute safety in diagnostic procedures.
The potential risk of thrombosis during coronary angiography using nonionic contrast media.
TLDR
The influence of contrast media on coagulation has an important association with thromboembolic complication during coronary angiography and the thrombotic propensity of contrast agents can be evaluated by measuring the clot formation of the mixtures.
Effects of an ionic versus a nonionic low osmolar contrast agent on the thrombotic complications of coronary angioplasty.
TLDR
Using multivariate analysis, use of the nonionic agent rather than the ionic agent emerged as an independent predictor of acute in-laboratory rethrombosis in patients undergoing PTCA.
In vitro study of the inhibition of coagulation induced by different radiocontrast molecules.
TLDR
The anticoagulant activity of seven intravascular radiocontrast molecules (RCM) was evaluated in different in vitro systems using citrated human plasma and potentiated the anti-thrombin action of heparin but the inhibition or delay of fibrinoformation is not related to an antithrombinic effect of contrast media.
Role of low-osmolality contrast media in thromboembolic complications: scanning electron microscopy study.
TLDR
Results indicate that nonionic, low-osmolality contrast media may play a role in the formation of thromboembolisms.
Alteration of coagulation mechanism of blood by contrast media.
  • H. Stein, M. Hilgartner
  • Medicine
    The American journal of roentgenology, radium therapy, and nuclear medicine
  • 1968
TLDR
The effect of radiopaque contrast media on the coagulation mechanism of man in vivo has not been previously evaluated and a thorough understanding of the deleterious effects of intravascular injection of contrast media is imperative.
Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media.
TLDR
It is concluded that nonionic contrast media significantly reduce the frequency of severe and potentially life-threatening ADRs to contrast media at all levels of risk and that use of these media represents the most effective means of increasing the safety of contrast media examinations.
Collagen-mediated platelet aggregation. Evidence for multivalent interactions of intermediate specificity between collagen and platelets.
TLDR
It is shown that the platelet aggregating abilities of Types I, II, and III fibrillar collagen are quite similar despite differences in carbohydrate content and amino acid sequence, and that the affinity of platelets for collagen depends upon prior polymerization of collagen.
Toxicity in animals and safety in humans: the predictive value of animal studies.
TLDR
Clinical results confirm the findings of animal studies that showed a two- to three-fold greater safety margin for non-ionic compounds than ionic compounds and the predictive value of pre-clinical safety assessment of iodinated contrast agents is re-examined.
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