Iontophoretic application of prostaglandin E1 for improvement in peripheral microcirculation.


OBJECTIVE The pharmacological effects of iontophoretically applied prostaglandin E1 (PGE1) on the peripheral microcirculation were investigated. MATERIAL AND METHOD PGE1 concentrations permeated through hairless mouse skin iontophoretically were measured by HPLC at hourly intervals. 19 patients with arteriosclerosis obliterans were given PGE1 (20 microg… (More)


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