Iontophoresis of 5-fluorouracil into the conjunctiva and sclera.

  title={Iontophoresis of 5-fluorouracil into the conjunctiva and sclera.},
  author={M Kondo and Makoto Araie},
  journal={Investigative ophthalmology & visual science},
  volume={30 3},
It was investigated in the rabbit eye whether the method of iontophoresis could introduce a sufficient amount of 5-fluorouracil (5-FU) to inhibit fibroblast proliferation into the conjunctiva and sclera, thus considerably reducing the total amount of 5-FU which must be given to the eye. Five-FU was introduced with a simple apparatus which was filled with 5% 5-FU solution and connected to the negative pole of a current source. When the apparatus was placed over the cornea, the 5-FU penetration… CONTINUE READING