Ionotropic glutamate receptors and nitric oxide synthesis in the rat striatum.

Abstract

A population of interneurones in the rat striatum contain neuronal nitric oxide synthase (nNOS). The nitric oxide (NO)-cGMP pathway may modulate neurotransmission in this brain area but little is known about the physiological stimulator(s) of nNOS in striatal neurones. Exposure of intact striatal slices to N-methyl-D-aspartate (NMDA) (100 microM, 8 min) caused an almost two-fold increase in cGMP levels (EC50 approximately 25 microM), which was inhibited by the nNOS inhibitor N-omega-L-nitroarginine (IC50 approximately 70 nM) and by removing external Ca2+. Neither (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) nor the kainate receptor agonist (2S,4R)-4-methylglutamate increased basal cGMP levels. Thus, glutamatergic striatal inputs could stimulate a NO-cGMP pathway in the striatum via NMDA receptors but not via AMPA or kainate receptors.

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@article{East1996IonotropicGR, title={Ionotropic glutamate receptors and nitric oxide synthesis in the rat striatum.}, author={Shannon East and Adrian R. Parry-Jones and Jonathan M. Brotchie}, journal={Neuroreport}, year={1996}, volume={8 1}, pages={71-5} }