Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia.

@article{Gao2000IonotropicGR,
  title={Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia.},
  author={Xiumei Gao and Kazuya Sakai and Rosalinda C. Roberts and Robert R. Conley and Brian Dean and Carol A. Tamminga},
  journal={The American journal of psychiatry},
  year={2000},
  volume={157 7},
  pages={1141-9}
}
OBJECTIVE Multiple quantifiable biologic abnormalities have been localized to the hippocampus in schizophrenia. Alterations in glutamate-mediated transmission at N-methyl-D-aspartic acid (NMDA)-sensitive receptors in hippocampus have been implicated in the pathophysiology of the illness. The authors tested the hypothesis that glutamatergic transmission within and efferent from hippocampus is altered in schizophrenia. METHOD The authors analyzed postmortem hippocampal tissue from individuals… CONTINUE READING
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